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Anti-CD8 Polyclonal Antibody
產(chǎn)品簡介：

Anti-CD8 Polyclonal Antibody
應(yīng)用 WB
稀釋比例WB 1:3000.
交叉反應(yīng)Mouse

產(chǎn)品型號：K106402P

更新時間：2022-08-15

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產(chǎn)品介紹

Anti-CD8 Polyclonal Antibody

英文名稱Anti-CD8 Polyclonal Antibody
宿主Rabbit
別名CD8A;MAL;Leu2;p32;OKT8 T cell antigen
應(yīng)用WB
稀釋比例WB 1:3000.
交叉反應(yīng)Mouse
蛋白分子量28kDa
Gene ID925
保存Store at -20°C. Avoid freeze / thaw cycles.
儲存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原A synthetic peptide of human CD8
性狀液體
Public Immunogen RangeA synthetic peptide of human CD8
Subcellular LocationsCell membrane
Swiss ProtP01732
克隆類型Polyclonal Antibody
背景資料Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.

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