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Anti-PDX1 Polyclonal Antibody
產(chǎn)品簡介：

Anti-PDX1 Polyclonal Antibody
應(yīng)用 WB IHC
稀釋比例WB 1:2000-5000.IHC 1:50-200.
交叉反應(yīng)Human Mouse Rat

產(chǎn)品型號：K106453P

更新時間：2022-08-15

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產(chǎn)品介紹

Anti-PDX1 Polyclonal Antibody

英文名稱Anti-PDX1 Polyclonal Antibody
宿主Rabbit
別名GSF;IDX-1;IPF1;IUF1;MODY4;PAGEN1;PDX-1;STF-1
應(yīng)用WB IHC
稀釋比例WB 1:2000-5000.IHC 1:50-200.
交叉反應(yīng)Human Mouse Rat
蛋白分子量48kDa
Gene ID3651
保存Store at -20°C. Avoid freeze / thaw cycles.
儲存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原A synthetic peptide of human PDX1
性狀液體
Public Immunogen RangeA synthetic peptide of human PDX1
Subcellular LocationsCytoplasm Nucleus cytosol
Swiss ProtP52945
克隆類型Polyclonal Antibody
背景資料Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

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