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產(chǎn)品中心抗體Polyclonal AntibodyK106457PAnti-c-fos Polyclonal Antibody
產(chǎn)品型號：K106457P
更新時間：2022-08-15
廠商性質(zhì)：生產(chǎn)廠家
訪 問 量 ：1044
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產(chǎn)品分類
Anti-c-fos Polyclonal Antibody
| 英文名稱 | Anti-c-fos Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | FOS;G0S7;AP-1;p55 |
| 應(yīng)用 | IHC |
| 稀釋比例 | IHC 1:50-200. |
| 交叉反應(yīng) | Human |
| 蛋白分子量 | 53kDa |
| Gene ID | 2353 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | A synthetic peptide of human c-fos |
| 性狀 | 液體 |
| Public Immunogen Range | A synthetic peptide of human c-fos |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | P01100 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum |
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