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產(chǎn)品中心抗體Polyclonal AntibodyK106537PAnti-PTEN Polyclonal Antibody
產(chǎn)品型號(hào)：K106537P
更新時(shí)間：2022-08-15
廠商性質(zhì)：生產(chǎn)廠家
訪 問(wèn) 量 ：923
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產(chǎn)品分類
Anti-PTEN Polyclonal Antibody
| 英文名稱 | Anti-PTEN Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | 10q23del;BZS;CWS1;DEC;GLM2;MHAM;MMAC1;PTEN1;PTENbeta;TEP1 |
| 應(yīng)用 | WB |
| 稀釋比例 | WB 1:3000. |
| 交叉反應(yīng) | Human Mouse Rat |
| 蛋白分子量 | 47kDa |
| Gene ID | 5728 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲(chǔ)存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | A synthetic peptide of human PTEN |
| 性狀 | 液體 |
| Public Immunogen Range | A synthetic peptide of human PTEN |
| Subcellular Locations | Cytoplasm Nucleus PML body Secreted |
| Swiss Prot | P60484 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. |
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