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產(chǎn)品中心抗體Polyclonal AntibodyK106621PAnti-SMAD4 Polyclonal Antibody
產(chǎn)品型號：K106621P
更新時間：2022-08-15
廠商性質(zhì)：生產(chǎn)廠家
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產(chǎn)品分類
Anti-SMAD4 Polyclonal Antibody
| 英文名稱 | Anti-SMAD4 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | DPC4;hSMAD4;JIP;MAD homolog 4;MADH4;Mothers against DPP homolog 4;SMAD 4;SMAD family member 4;SMAD4 |
| 應(yīng)用 | WB |
| 稀釋比例 | WB 1:500-2000. |
| 交叉反應(yīng) | Human |
| 蛋白分子量 | 60kDa |
| Gene ID | 4089 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | Recombinant protein of human SMAD4 |
| 性狀 | 液體 |
| Public Immunogen Range | Recombinant protein of human SMAD4 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | Q13485 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. |
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