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Anti-CDK4 Polyclonal Antibody
產(chǎn)品簡介：

Anti-CDK4 Polyclonal Antibody
應用 IHC
稀釋比例IHC 1:50-200.
交叉反應Human

產(chǎn)品型號：K106719P

更新時間：2022-08-15

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產(chǎn)品介紹

Anti-CDK4 Polyclonal Antibody 

英文名稱Anti-CDK4 Polyclonal Antibody
宿主Rabbit
別名CDK4;Cell division protein kinase 4;CMM3;cyclin dependent kinase 4;PSK J3
應用IHC
稀釋比例IHC 1:50-200.
交叉反應Human
蛋白分子量34kDa
Gene ID1019
保存Store at -20°C. Avoid freeze / thaw cycles.
儲存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原Recombinant protein of human CDK4
性狀液體
Public Immunogen RangeRecombinant protein of human CDK4
Subcellular LocationsCytoplasm Nucleus
Swiss ProtP11802
克隆類型Polyclonal Antibody
背景資料The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers.

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